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Patient Populations Where Combination Therapy May Be Appropriate Combination topiramate-semaglutide may be considered in obese patients with concurrent migraines, epilepsy, or mood disorders where topiramate provides dual therapeutic benefit

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Available treatments such as levodopa, dopamine agonists and monoamine oxidase B inhibitors offer only symptomatic relief however, they do not treat the underlying neurodegeneration, emphasising the need for neuroprotective management